ISSN 1662-4009 (online)

ey0016.3-4 | Thyroid Hormone Action | ESPEYB16

3.4. Non-thyroidal illness syndrome in critically ill children: prognostic value and impact of nutritional management

A Jacobs , I Derese , Perre S Vander , Puffelen E van , S Verstraete , L Pauwels , S Verbruggen , P Wouters , L Langouche , Guerra G Garcia , K Joosten , I Vanhorebeek , Berghe G Van den

To read the full abstract: Thyroid. 2019;29:480–492.The thyroid axis is particularly responsive to critical illness. Adaptation processes of the thyroid axis to critical illness and prolonged fasting are well described as non-thyroidal illness syndrome. Non-thyroidal illness is mainly explained by two mechanisms: 1) peripheral inactivation of T4 to rT3 by decreased type-1 deiodinase...